Analysis of Several Inflammatory Markers Expression in Obese Rats given Plectranthus amboinicus (Lour.) Spreng Ethanol Extract

Introduction: Oxidative stress is one of the inflammatory events caused by obesity. This condition characterized an increase in various markers, such as intercellular adhesion molecule 1 (ICAM-1), vascular cell (VCAM-1), and a cluster differentiation 40 (CD40). study aimed to analyze effect Plectranthus amboinicus (Lour.) Spreng ethanol extract on ICAM-1, VCAM-1, CD40 obese rats. Methods: The used pure experimental method with completely randomized design. There were 6 groups, namely, C− (negative control), C+ (positive CMC (soluble EE300 (P. extract, 300 mg/kg body weight [BW]), EE600 600 BW) EE900 groups 900 BW). Results: results showed low levels ICAM-1 VCAM-1 blood plasma, especially group, but difference was not substantial. same trend also occurred expression tunica intima layer rat aorta. Conclusions: Thus, administration BW P. for 45 days has potential treat obesity rats through suppression oxidative markers (ICAM-1, CD40).